Nagalase is an enzyme produced by cancer cells that help it to hide from the immune system.
In general, the best way to lower (or eliminate) the production of this enzyme is to kill the cancer but there are two therapies in particular that are good at enabling the immune system to better identify the cancer cells that need to be eliminated without harming normal cells.
First I’ll explain GcMAF. The Gc is a description of the type of protein this consists of. The MAF stands for “Macrophage Activating Factor”. The macrophage white blood cell (that we all have in our system) is part of our immune system whose main job is to identify and kill any abnormal cells (like cancer cells).
The Nagalase enzyme blocks the vitamin D receptor sites on the macrophage cells so they cannot “see” the cancer cells. It is a survival mechanism for the cancer cells.
What the GcMAF therapy does is restore the ability of the macrophage cells to detect the cancer cells and then attack and kill them.
When this happens, the production of Nagalase is reduced and the blood levels go down so it becomes easier for the immune system to detect the presence of any remaining cancer cells.
Salicinium, the second therapy that will lower Nagalase levels, is a naturally occurring “glyco-benzaldehyde”. This compound falls into the category of a “nano-particulate conjugate”. What this means is it is a chemical compound binding a sugar molecule to a benzaldehyde molecule.
Sugar is the taxi cab and the benzaldehyde is the passenger. When the compound enters (only) the cancer cells an enzyme breaks the bond between them. Free benzaldehyde is toxic to the energy production pathway in the abnormal cells. This weakens and/or kills the cell causing a drop in the nagalase that allows the immune system to recognize how abnormal the cancer cells are and begin to attack the remaining tumor cells.
In addition to a drop in nagalase blood levels, salicinium has been shown to increase the strength of the immune system by causing an increase in immunoglobulin production (a tool the white blood cells use to kill abnormal cells). It also triggers an increase in the total white blood cell (a big part of the immune system) count.
Both of these therapies are very valuable additions to the ongoing search for the end of this dreadful disease.
How do we test for Nagalase?